Thesis (PHD) - University of Aston in Birmingham, 1981.
Prazosin is believed to have an antihypertensive action due to a selective blockade of alpha-adrenoceptors on vascular smooth muscle. Using an in vitro autoradiographic technique specific binding of [3H]prazosin to the abdominal aorta and renal artery in the rat has been by: 7. On the endothelium-intact rat aorta some studies have shown prazosin to cause nonparallel rightward shifts of α1-adrenoceptor agonist response curves. The aim of the present study was to analyze the inhibitory effect of prazosin on the phenylephrine responses of the endothelium-intact and endothelium-denuded rat aorta. Firstly I used phenoxybenzamine treatment to characterize the Cited by: 6. 1. The cardiovascular effects of prazosin, a new antihypertensive drug, were studied in normotensive and genetically hypertensive rats. 2. Prazosin, infused intra‐arterially, lowered vascular resista Cited by: In another study, hybrid tetra-amine disulfides were synthesized by combining the structural features of Prazosin, and Benextramine, an irreversible α1/α2-adrenoreceptor antagonist, and their biological profiles were assessed in isolated rat vas deferens (α1A), spleen (α1B), and aorta (α1D), revealing that the disulfide bridge of these.
Certainly selective bloc- kade of al-adrenoceptors in vascular tissue, by prazosin, might explain any peripheral antihyper- tensive action. In the isolated rat aorta preparation prazosin inhibits the contractile response to noradrenaline and phenylephrine (Downing et al., ). Prazosin, an antagonist of alpha 1-adrenergic receptors, has been found to suppress the clinical and histological expression of experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. Suppression was more significant in females than in males and was a dose-dependent phenomenon. Analysis of the effect of other adrenergic receptor antagonists supports the conclusion that the. The present investigation was carried out in order to study the cAMP system in SHR aorta and to elucidate the mechanism of action of prazosin (1-[4 amino-6,7 dimethoxyquinazoline][2 furoyl]-piperazine), a new antihypertensive drug. It is known that this drug acts essentially as an a -blocking agent (Cambridge et al., ). Start studying prazosin. Learn vocabulary, terms, and more with flashcards, games, and other study tools. games, and other study tools. Search. Create. Log in Sign up. Log in Sign up. 10 terms. johnsonmo prazosin. STUDY. PLAY. classification of prazosin. vascular alpha 1 adrenergic antagonist. mechanism of action for prazosin. blocks.
Prazosin ( or 1 mg/kg) was injected subcutaneously (s.c.) to conscious normotensive rats, either alone or in combination with the β‐adrenoceptor antagonist, dl ‐propranolol (1 or 3 mg/kg). Rats bore chronically implanted dorsal aorta cannula for measurement of blood pressure and heart rate and blood sampling for renin determinations. The in vivo metabolism of prazosin in rat was first reported in , although at the time analytical techniques were not as sophisticated, nor were the mass spectrometers as sensitive, as today. Recently, the in vitro metabolism of prazosin in rat liver microsomes and cryopreserved hepatocytes was investigated using liquid chromatography/mass. Patient was educated on Prazosin and its mechanism of action as follows: Prazosin inhibits the action of catecholamines (adrenaline and noradrenaline) on the Alpha-1 receptors of the blood vessels (both arteries and veins). Action of catecholamines on Alpha-1 receptors result in constriction of arteries and veins. Inhibition of the catecholamine action on these receptors result [ ]. Wollersheim H, Thien T. Dose-response study of prazosin in Raynaud's phenomenon: clinical effectiveness versus side effects. J Clin Pharmacol ; Wollersheim H, Thien T, Fennis J, van Elteren P, van't Laar A. Double-blind, placebo-controlled study of prazosin in Raynaud's phenomenon. Clin Pharmacol Ther ;